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@bigbio

BigBio Stack

Provide big data solutions Bioinformatics

Welcome to bigbio 👋

bigbio is an open-source organization dedicated to advancing bioinformatics and computational proteomics and multiomics research. We develop scalable tools, workflows, and libraries to support complex experimental designs in proteomics, genomics and multiomics. Our mission is to empower researchers with accessible, efficient, and cutting-edge solutions for data analysis and integration.

🌟 Key Projects

🔬 Proteomics and Quantitative Analysis

  • quantms: A comprehensive workflow for proteomics experiments supporting DDA-LFQ, DDA-Isobaric, and DIA-LFQ quantification.
  • qpx: A proteomics quantification format extending mzTab for large-scale datasets.
  • ibaqpy: A package for absolute quantification based on the quantms.io format.
  • quantms.org: Code for quantms.org, a resource for reanalysis and public proteomics data.

🧪 Multiomics and Metadata Tools

⚡ Workflow Utilities

  • pmultiqc: A QC report library based on the MultiQC framework.
  • spectrafuse: An incremental clustering pipeline for quantms data.
  • quantms-utils: Helper scripts and classes for the quantms workflow.
  • quantms-rescoring: Helper functions and scripts for quantms and ms2rescore.

🤝 Contributions

We welcome contributions from the community! Whether it's bug fixes, feature suggestions, or documentation improvements, every contribution helps drive bioinformatics research forward.

🔗 Stay Connected

Join us on this journey to revolutionize data analysis in proteomics and beyond!

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  1. proteomics-sample-metadata proteomics-sample-metadata Public

    The Proteomics sample metadata: Standard for experimental design annotation in proteomics datasets

    HTML 100 116

  2. quantms quantms Public

    Quantitative mass spectrometry workflow. Currently supports proteomics experiments with complex experimental designs for DDA-LFQ, DDA-Isobaric and DIA-LFQ quantification.

    Nextflow 68 54

Repositories

Showing 10 of 57 repositories
  • quantmsdiann Public

    quantms workflow for DIANN tool including DIA and DDA analysis

    bigbio/quantmsdiann’s past year of commit activity
    1 MIT 3 12 0 Updated Mar 23, 2026
  • quantms Public

    Quantitative mass spectrometry workflow. Currently supports proteomics experiments with complex experimental designs for DDA-LFQ, DDA-Isobaric and DIA-LFQ quantification.

    bigbio/quantms’s past year of commit activity
    Nextflow 68 MIT 54 47 (2 issues need help) 2 Updated Mar 23, 2026
  • nf-modules Public

    quantms and other bigbio workflows modules in nf-core, nextflow standards

    bigbio/nf-modules’s past year of commit activity
    Nextflow 0 MIT 3 1 1 Updated Mar 22, 2026
  • hvantk Public

    Hail variant annotation toolkit

    bigbio/hvantk’s past year of commit activity
    Python 0 MIT 0 5 (1 issue needs help) 0 Updated Mar 22, 2026
  • qpx Public

    qpx (Quantitative Proteomics eXchange) format (aka quantms.io) a format to capture a full proteomics experiment

    bigbio/qpx’s past year of commit activity
    Python 16 Apache-2.0 6 22 (1 issue needs help) 1 Updated Mar 22, 2026
  • sdrf-pipelines Public

    `sdrf-pipelines` is the official SDRF file validator and converts SDRF to pipeline configuration files

    bigbio/sdrf-pipelines’s past year of commit activity
    Python 29 Apache-2.0 29 37 (5 issues need help) 1 Updated Mar 22, 2026
  • quantms-utils Public

    A python library with scripts and helpers classes for quantms workflow

    bigbio/quantms-utils’s past year of commit activity
    Python 6 MIT 4 0 0 Updated Mar 21, 2026
  • mokume Public

    Integrated library to perform feature normalization and multiple abundance computing based on qpx

    bigbio/mokume’s past year of commit activity
    Python 1 MIT 2 1 0 Updated Mar 21, 2026
  • sdrf-templates Public

    SDRF templates and validation yaml files from specification proteomics-sample-metadata

    bigbio/sdrf-templates’s past year of commit activity
    Python 1 Apache-2.0 5 1 1 Updated Mar 20, 2026
  • sdrf-skills Public

    SDRF skills that enables to perform multiple tasks on SDRF annotations - validations using Claude

    bigbio/sdrf-skills’s past year of commit activity
    1 MIT 0 0 1 Updated Mar 20, 2026

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